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Keynotes

By Domenick Falcone, PhD

In February 2005, Dr. Rebecca N. Baergen presented at the annual meeting of the Society for Maternal-Fetal Medicine on the "Ultrasound evaluation of abnormal umbilical cord coiling in second trimester of gestation as a predictor of adverse pregnancy outcome." Also in February, she presented at the USCAP meeting: "Double immunostaining for cytokeratin and collagen IV is useful for detection of microinvasion in vulvar and cervical intraepithelial neoplasia" and "Antiphospholipid syndrome and placental deposition of complement C4d." Presentations at the Society for Gynecologic Investigations included "Regulation of glucocorticoid receptor expression in intrauterine growth restricted placentas," and "Glucocorticoid receptor expression and function in the human placenta." Dr. Baergen served on the Abstract Board for the United States and Canadian Academy of Pathology, Director of the Perinatal Section of the Society for Pediatric Pathology, and Director of the annual Perinatal Symposium sponsored by the Society for Pediatric Pathology in October. In April 2005, she presented a paper on "Umbilical cord complications and adverse perinatal outcome" at the Havemayer Foundations Workshop on Comparative Placentology in Victoria, Vancouver. In May 2005, Dr. Baergen served as a faculty member in the Perinatal Course sponsored by the Society for Pediatric Pathology and Perinatal Section. She continues as a member of the Committee on Human Rights in Research and the Institutional Research Board, as well as the Adverse Events Subcommittee. She has been appointed a member of the Medical Devices Advisory committee of the Food and Drug Administration.

Dr. Andrea Cerutti was awarded a new five year grant ($1,250,000) from the National Institute of Allergy and Infectious Diseases to study the regulation of antibody production by innate immune cells. In February 2005, Dr. Cerutti was in Bethesda to serve on a special committee to review grant applications submitted to the NIAMS branch of NIH. In March 2005, Dr. Cerutti was an invited lecturer at the Oklahoma Medical Research Foundation, where he presented data on the role of the B cell-activating molecules BAFF and APRIL in health and disease. In August 2005, Dr. Cerutti was in Rockville to serve on a scientific advisory board for the evaluation of the clinical activity of LymphoStatŪ, a compound produced by Human Genome Sciences, and gave a seminar on the role of BAFF and APRIL in B cell lymphoma. In September 2005, Dr. Cerutti served on a special review committee for grant applications submitted to NIAMS. In the same month, Dr. Cerutti was an invited speaker at the Sjogren's Syndrome Foundation workshop "Sjogren's Syndrome: Transition from Autoimmunity to Lymphoma," which was held in Baltimore. Finally, Dr. Cerutti was chosen by the Graduate Program in Immunology and Microbial Pathogenesis to serve as Director of the Research in Progress (RIP) Course. In addition, Dr. Cerutti has been responsible for the organization of the Pathology Research Seminar Series.

Dr. Ethel Cesarman serves in the Immunology Program of the Weill-Cornell Graduate School of Medical Sciences as Director of the course on Fundamental Immunology. During the past year she served as reviewer for the National Cancer Institute Special Emphasis Panel/ Scientific Review Group. She served as an external reviewer for "Cancer Research UK" in the evaluation of the UK Viral Oncology Group in the University College of London. She participated among a small group of selected experts in a Workshop on Viral and Environmental Links to Lymphoma, organized by the Cancer Etiology Branch and the Division of Cancer Biology of the National Cancer Institute, in Bethesda, MD. Dr. Cesarman gave a Keynote Lecture on work from her research laboratory on the topic of pathogenesis associated with infection with the Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) and other viral lymphomas at the "Congreso Nacional de Bioquimica," in Ixtapa, Mexico. She was also invited to give a talk on the same topic at the Boston Area Herpesvirus Seminar Series, Brigham and Women's Hospital of Harvard University. Her laboratory was represented at several scientific meetings. Botond Timar gave an oral presentation entitled "Activation of classical and alternative nuclear factor-kappa B (NF-kB) pathways in diffuse large B cell lymphomas" at the American Society of Hematology Meeting in San Diego, last December. Three members of her laboratory had oral presentations at the 8th International Workshop on KSHV and Related Agents, in Wilbad Kreuth, Germany in August. Darya Bubman gave a talk entitled "Reactive oxygen species (ROS) are induced by vFLIP and play a role in NF-kB activation." Ilaria Guasparri presented "The KSHV oncoprotein vFLIP contains a TRAF-interacting motif and requires TRAF2 and TRAF3 for signaling," and Denise Hernandez-Hopkins was first author on a presentation entitled "In vivo imaging of primary effusion lymphomas in mice, and effective treatment by inhibition of NF-kB." Daniel Di Bartolo presented a poster entitled "Repression of TGFb signaling in primary effusion lymphomas" in the Workshop on Viral Oncogenes in Santa Fe, NM, in September. Dr. Cesarman also represented her laboratory with an oral presentation at the 9th International Confer-ence on malignancies in AIDS and Other Acquired Immunodeficiencies: Basic, Epidemiologic and Clinical Research, in Bethesda, MD in September.

Dr. Amy Chadburn attended the 2005 United States and Canadian Academy of Pathology (USCAP) meeting in San Antonio, TX, in association with six abstracts presented by trainees in the department. In April she coorganized and co-chaired the Nassau County Society of Pathology Spring Seminar held in Mineloa, NY. At the conference she discussed "Problem Areas in B-cell Lymphoma Diagnosis." The following week she flew to Rome, Italy, as part of the International Symposium: Infection-Driven Lymphomas where she spoke on "Immunosuppression and Lymphomagenesis" as part of the opening lectures (she was also there for the "white smoke" from the Vatican). In June she traveled to the University of California – Los Angeles Medical Center where she visited the Pathology Department and gave a lecture on "Immunodeficiency-Associated Lymphoproliferative Disorders." In September she traveled to the University of Arkansas Medical School Pathology Department where she lectured on the WHO classification of "Immunodeficiency-Associated Lymphoproliferative Disorders." During the month of October she reviewed abstracts for the hematopathology section of the USCAP submitted for the 2006 Atlanta, GA meeting. In the last six months she has also been selected to serve on the membership committee for the Society of Hematopathology.

Starting July 1, 2004, Dr. Selina Chen-Kiang has been Director of the Graduate Program in Immunology and Microbial Pathogenesis of the Weill-Cornell Graduate School of Medical Sciences. In this capacity, she oversees the recruitment, admission and education of ~ 50 graduate students and MD-PhD students who are pursuing their PhD thesis research in 34 independent laboratories at Weill-Cornell, Sloan Kettering Cancer Institute and the Hospital for Special Surgery. Dr. Selina Chen-Kiang has been extremely active in extramural grant reviews. She is a member of the National Cancer Institute SPORE Parent Committee, which reviews SPORE cancer grants of all organs, in addition to serving as an ad hoc reviewer for the NIH Cancer Molecular Pathology Study Section and a member of the Intramural Program Review Panel. She is also a member of the Medical and Scientific Committee of the Leukemia and Lymphoma Society, which oversees reviews of Leukemia and Lymphoma Society grants of all levels, and a member of the Professional Education Subcommittee of the Leukemia and Lymphoma Society, which defines the themes and future focus of the Society's educational programs. Additionally, she sits on the Board of Directors of the New York Chapter of the Leukemia and Lymphoma Society. Dr. Selina Chen-Kiang has been an organizer and invited speaker at numerous international conferences in the past year. In 2004, she was an invited speaker on "Essential role of Cdk inhibitor in plasma cell differentiation" at the Cold Spring Harbor Immune Regulation Meeting in April; on "p18 control of B cell activation and plasma cell differentiation" at the FASEB Lymphocytes and Antibodies Conference in Vermont in June; on "Homeostatic cell cycle control of B cell activation by BLyS" at the NCI Potter Symposium in Bethesda in July; a keynote speaker on "Cell cycle dysregulation in multiple myeloma" at the Lymphoma and Myeloma Workshop in New York in October; and on "Cdk inhibitor control of B cell activation and plasma cell differentiation" at the International Workshop on Cell Death, Cell Cycle, Cell

Senescence in Japan in November. Since 2005, she has been invited to speak on "Dysregulation of G1 cell cycle checkpoints in multiple myeloma" at the International Workshop on Multiple Myeloma in Australia in April; on "Control of multiple myeloma by cyclin-dependent kinase inhibitors" at the ASCO Annual Meeting in Florida in May. She also chaired a session on myeloma biology at the ASH Annual Meeting in December of 2005. In between organizing and speaking at meetings, Dr. Selina Chen-Kiang is a frequently invited seminar speaker. These include seminars on "Cell cycle control of self-renewal in multiple myeloma" at the University of Massachusetts Medial Center and on "Cdk inhibitor control of B cell terminal differentiation" at NCI in May of 2005.

Dr. Yao-Tseng Chen was invited as a keynote speaker in the Moscow Conference on Computational Molecular Biology, held in July 18-21 this year at Moscow State University. His presentation, titled "Identification of new cancer/testis antigens by massively parallel signature sequencing," summarized his recently published work in Proc. Natl. Acad. Sci. USA; this paper was also showcased in the "Research Highlights" section in "Nature Review: Cancer."

In collaboration with Dr. Yao Chen, Dr. Scott Ely has been studying CT antigen expression and function in lymphomas and plasma cell neoplasms. This work has been presented at the ASH meeting in San Diego (2004), at the United States and Canadian Academy of Pathology meeting in San Antonio (2005), and in the upcoming ASH meeting in Atlanta, GA (2005). Dr. Ely presented "Blastoid Transformation of Mantle Cell Lymphoma" at the New York City Pathologists Club's November meeting at North Shore University Hospital. Dr. Ely is a consultant for an NIH-funded program project entitled "Doxorubicin-Immunoconjugate Therapy of NHL" at the Center for Molecular Medicine and Immunology in Belleville, NJ.

Drs. Domenick J. Falcone and K.M. Faisal Khan attended the annual meeting of the American Association of Experimental Pathology in San Diego, CA (April, 2005), where they presented two posters: "Targeting PGE2 receptors as a strategy to block extracellular matrix-induced MMP-9 expression by macrophages" and "Membrane-bound plasmin participates in a proteinase cascade responsible for macrophage activation of pro-MMP-9." In addition to his NHLBI sponsored research, Dr. Falcone received a two year grant from the Center for Cancer Prevention to study extracellular matrix induction of proteinases by tumor cells. In June, Dr. Falcone was invited to present a lecture on "Web-based Innovations in Teaching Histology," during the annual Medical College teaching retreat, and received awards for teaching excellence in the Host Defenses course, and for the development of the Web-based Atlas of Histology.

Dr. Syed Hoda lectured at various national and international meetings in multiple locations including the following: on "Emerging Pathology Issues in Breast Cancer" at the School of Breast Oncology (SOBO) at Emory in Atlanta, GA in November 2004; on "Controversial Issues in Pathology of Breast Carcinoma" at the Mexican Academy of Cytopathology in Monterrey, Mexico, in December 2004; on "The Pap Smear: Current Criteria and Changing Concepts" at USCAP in March 2005. American Society of Clinical Pathologists (ASCP) Weekends in Pathology in Toronto, Canada in April 2005 on Pathology of Needle Core Biopsies of Breast on "Pathological Effects of Cryoablation on Breast Tumors" American College of Surgeons Oncology Group (ACOSOG) in Chicago, IL, in June 2005; on "Issues in Diagnostic Breast Pathology" University of Kyoto, Japan, in August 2005; on "Practical Considerations in Differential Diagnosis in Pap Smear" and on "Pathology of Sentinel Lymph Nodes in Breast Carcinoma" at the annual ASCP meeting in Seattle in October 2005. In the same month, Dr. Hoda also delivered multiple lectures at the Second New Zealand National Breast Conference in Auckland including one during the plenary session entitled "New Frontiers in Breast Pathology." This year, Dr Syed Hoda was reelected Secretary of the New York Pathological Society.

Dr. Daniel Knowles, Chairman and Pathologist-in-Chief, actively participated in the Annual Meeting of the United States and Canadian Academy of Pathology held in San Antonio, Texas in March, 2005. In addition to attending the annual meetings of several Editorial Boards upon which he serves, Dr. Knowles co-authored five abstracts with other members of the Cornell Hematopathology group as well as with house staff and fellows. He participated in the Sixth Annual Pathology Update sponsored by the Department of Pathology and Laboratory Medicine at the University of Louisville in May 2005. There, he lectured on "AIDS-Associated Lymphoid Neoplasia" and "Immunodeficiency-Associated Lymphoproliferative Disorders." A few days later he visited the Methodist Hospital in Houston, Texas, reviewing the Department of Pathology with Dr. Michael Lieberman and also presenting "Primary Effusion Lymphoma: A New Clinical Pathologic Entity Associated with Kaposi's Sarcoma-Associated Herpes Virus" at the Methodist Hospital Grand Rounds. In his capacity as President of the New York Pathological Society Dr. Knowles developed and chaired the New York Pathological Society President's Symposium on "Molecular Pathology of Neoplasia" held in June 2005. Two members of the Department, Drs. Debra G.B. Leonard and Lynn Wang, were among the five speakers at the Symposium. In September, Dr. Knowles attended the Annual Meeting of the North East Pathology Chairs in Bermuda where he participated in discussions concerning pathology resident education and training.

This year Dr. Davise Larone was selected by the Medical Mycological Society of the Americas to receive the annual Billy H. Cooper Memorial Award for excellence in clinical research, laboratory diagnostic procedures, and teaching. The award is conferred upon an individual who has contributed substantially to the clinical applications of medical mycology, particularly in laboratory diagnosis and recognition of mycoses. Dr. Larone conducted full-day Clinical Mycology Workshops for the Southeastern Association for Clinical Microbiology in Myrtle Beach, SC in November, 2004 and for the Southwestern Association in Tulsa, OK in September, 2005. In November 2004, she was invited to present an "Update on Clinical Mycology" to the Illinois Society for Microbiology in Chicago, IL and a lecture on "Antifungal Susceptibility Testing" at a seminar on Resistance Testing Challenges in Atlanta, GA in March, 2005. At a seminar on Technological Advances in Microbiology in Atlanta in June, 2005, she spoke on "New Mycology Media for the Clinical Laboratory." At the annual meeting of the Pan American Society for Clinical Virology in Clearwater, FL in May, 2005, Dr. Larone presented "Decreasing Indeterminant Results with BD ProbeTec ET Chlamydia trachomatis and Neisseria gonorrhoeae," and she was coauthor of an abstract entitled "Use of Polymyxin B in the Treatment of Multidrug-resistant (MDR) Acinetobacter baumannii Infection on a Burn Unit" which was presented at the Annual Meeting of the American Burn Association. At the annual national meeting of the American Society for Microbiology in Atlanta in June 2005, Dr. Larone, with several pathology residents, presented three posters: "CHROMagar Candida as a Source Medium for Isolates to be Tested with the New VITEK 2 Yeast Identification Card" and "Comparative Study of the New Colorimetric Vitek 2 Yeast Identification Card vs the Older Fluorometric Vitek 2 Yeast Card" with Drs. Cheri Aubertine, Michael Rivera, and Stephen Rohan, and "Stability of Mueller-Hinton Agar Plates Flooded with Glucose and Methylene Blue for Fluconazole Disk Diffusion Testing of Candida Species" with Drs. Matthew Bramlage and Theresa Scognamiglio.

Dr. Ehud Lavi's laboratory is focusing on Neurovirology and Neuroimmunology projects using an experimental model system of coronavirus infection of the mouse brain, a model system for the human multiple sclerosis disease. Two research articles from the lab were recently submitted. The first article reports the identification of a single point mutation in the MHV coronavirus genome that abolishes the ability of the virus to cause demyelination in mice. The second article analyzes the differential quantitative Real-time PCR transcript profile of pro-inflammatory cytokine signals in astrocytes and microglia following infections of cell cultures with neurotropic and non-neurotropic viruses. With the help of Dr. Cris Constantinescu from the University of Nottingham in the UK, Dr. Lavi edited a book entitled "Experimental Models of Multiple Sclerosis," to be published in November 2005 by "Springer Publishing Company." Dr. Lavi gave the first video-sessions of the Neuropathology Module of Brain and Mind to the medical students of Cornell Medical School in Qatar.

Dr. William A. Muller served as President of the North American Vascular Biology Organization (NAVBO) as well as Chairman of the FASEB Summer Research Conferences Advisory Committee. He was appointed to the Editorial Committee of the newly founded Annual Review of Pathology: Mechanisms of Disease. He began a three-year term as a Charter Member of the Atherosclerosis and Inflammation in the Cardiovascular System (AICS) study section for the NIH. He continues to serve as Editor of the Journal of Experimental Medicine. At Weill Medical College he is Chairman of the General Faculty Council and serves on more committees than he can count, including the Committee of Review, the Committee on Science, the Conflicts Advisory Panel, the Research Awards Committee; for the Graduate Program in Immunology he heads the NIH Training Grant and serves on the Admissions Committee and the Admission to Candidacy Exam Committee. This year Dr. Muller received a MERIT Award from the NIH for his pioneering work on the molecular basis of inflammation. He was an invited speaker at many national and international scientific meetings within the past year including the Keystone Symposium on Atherosclerosis, the American Society for Investigative Pathology national meeting in San Diego, the Gordon Conference on Wound Repair, the Gordon Conference on Atherosclerosis, and the International Leukocyte Biology Meeting in Oxford, UK. The topic at these meetings was "Cellular and Molecular Control of Transendothelial Migration by Leukocytes." Along with several other NAVBO members, he ran Vasculata, a three day course on modern vascular biology for graduate students and postdoctoral fellows at Dartmouth College this July. Dr. Zahra Mamdouh and graduate student Bidisha Dasgupta from his laboratory were selected to present their work in a special mini-symposium on Leukocyte-Endothelial Cell Interactions at the Experimental Biology 2005 meeting in San Diego.

Dr. Ellinor Peerschke was elected President-elect of the Academy of Clinical Laboratory Physicians and Scientists in Pittsburgh, PA at the society's annual meeting in June. The Academy of Clinical Laboratory Physicians and Scientists represents individuals engaged in clinical practice and residency training in all areas of Laboratory Medicine in the United States. In addition, she was elected Vice President of the North American Specialty Coagulation Laboratory Association, an organization for which she serves as Chair of the Proficiency Testing Committee. Dr. Peerschke was invited to lecture on various topics in hemostasis during the past year, including a coagulation workshop in New York City in May sponsored by Stago Diagnostics, and a symposium on quality control in coagulation at the Mayo Clinic in Rochester, MN. In addition to her clinical interests, Dr. Peerschke conducts a research program examining the role of platelet and endothelial cell complement receptors in inflammation and infection, particularly S. aureus endocarditis. Her work has been presented at invited seminars in May at Temple University, Thrombosis Center, Philadelphia, PA, and in July at the Medical School of Zulia University in Maracaibo, Venezuela.

Dr. Edyta C. Pirog presented "Double immuno-staining for cytokeratin and basement membrane components is useful for detection of microinvasion in vulvar and cervical intraepithelial neoplasia" at the annual USCAP meeting. She also presented "PNET arising in ovarian teratoma" at the New York Pathology Club, Unknown Case Conference, in June 2005.

Dr. Surya Seshan coordinated the first ever three day International CME in Renal Pathology "Update on Medical and Surgical Diseases of the Kidney" at the Sanjay Gandhi postgraduate Institute of Medical Sciences, Lucknow, India, in March and presented several lectures on the pathology of primary glomerular diseases, vascular diseases of the kidney and classification of lupus glomerulonephritis and antiphospholipid antibody syndrome. She was elected "Councillor" by the Renal Pathology Society this year. In September, she attended the 20th European Congress of Pathology meeting in Paris, France and served as a cochairperson in a session on "Berger's IgA nephropathy and Henoch-Schonlein purpura" and was an invited speaker on "Vascular lesions in IgA nephropathy" and "Thrombotic microangiopathies – an overview" in a short course at the same meeting in Paris. Dr. Seshan was also busy lecturing in the tri-state area presenting grand rounds at Hospital for Special Surgery "Classification of lupus glomerulonephritis – an update," and was an invited speaker at a clinicopathologic conference at HSS last spring. She also presented grand rounds at the Department of Pathology of University Hospital, UMDNJ, Newark, NJ on "Glomerular and tubulo-interstitial diseases" in April and at the Department of Medicine of St. Joseph's Hospital and Medical Center, Paterson, New Jersey in "Paroxysmal nocturnal hemoglobinuria – a cause of acute and chronic renal failure" in June. Also in April, Dr. Seshan participated in the Renal Pathology Course on "Morphologic findings in Medical renal disease and transplants: with clinicopathological correlations" and gave lectures on "Pathology of acute renal failure including thrombotic microangiopathies" and "unusual renal lesions." Dr. Seshan was an invited speaker at the companion meeting of the Annual Meeting of the American Society of Clinical Pathologists in October in Seattle, WA on "Classification of lupus glomerulonephritis: New developments and implications." She was an author or coauthor of 15 abstract presentations in various national and international meetings.

Dr. Wayne Tam presented "PRDM1 Is a Tumor Suppressor Gene in Diffuse Large B-cell Lymphomas" at USCAP in March 2005. This seminal work identified PRDM1 as a tumor suppressor gene in this group of lymphomas. He is now continuing work to further understand the role of microRNAs and PRDM1 in lymphomagenesis and hopes that these new discoveries can lead to effective therapeutic strategies.

In April 2005, Drs. Rita Upmacis and Ruba Deeb attended the Experimental Biology 2005 meeting in San Diego, California, and presented "Deactivation of prostaglandin H2 synthase by peroxynitrite." Dr. Upmacis received a three-year award from Philip Morris USA and Philip Morris International to study "Deactivation Mechanisms of Cyclooxygenase." In January 2005, Dr. Upmacis was invited to serve on a doctoral thesis defense committee in the Department of Chemistry, Columbia University. In February 2005, Dr. Deeb was an invited speaker at the Atorvastatin Research Award summit meeting in Key Biscayne, Florida and presented a talk entitled "Structural and functional analysis of the deactivation of prostaglandin H2 synthase-1 by nitrogen oxide species."

Dr. Madeline F. Vazquez was named Chief of Cytopathology in August 2005. She is on the steering committee of the International Early Lung Cancer Action Program [I-ELCAP] and participated in the ASCO - IASLC Consensus Conference on Bronchioloalveolar Cell Carcinoma held at Memorial Sloan-Kettering Cancer Center in November 2004. She was also on the faculty of the refresher course "Screening for Lung Cancer" held at the annual meeting of the Radiological Society of North America in Chicago. Dr. Vazquez was the senior author on several abstracts presented at national meetings including; "Hybrid capture 2 high-risk human papillomavirus (HPV) DNA testing for atypical glandular cells (AGC): A crucial adjunct for cancer prevention" (presented by Anjali Saqi at American Society of Cytopathology, 52nd Annual Scientific Meeting, in Chicago, Illinois), "Ki-67 and p53 Antigen detection in aspiration biopsies of non-small cell carcinoma of the lung" (presented by N Cai at USCAP), "Is Her-2/neu status determined by immunohistochemistry in cell block preparations accurate and reliable? A concordance study of immunohistochemistry and fluorescence in-situ hybridization." (presented by Sandra Shin at USCAP), "Atypical bronchioloalveolar proliferation: A new cytologic category for lung aspiration biopsy representing a bronchioloalveolar growth pattern" (presented by JL Morhaime at USCAP) and "Chromosomal amplification as a molecular marker to predict neoplastic potential in fine needle biopsies of spiral CT identified small lung nodules" (presented by J Jen at the American Association for Cancer Research). In September 2005, Dr. Vazquez presented "CT-detected lung cancers in the Early Lung Cancer Action Project (ELCAP): Cytologic findings on transthoracic FNA" at Pathology Grand Rounds at University of Pittsburgh Medical Center Shadyside Hospital.

Dr. Y. Lynn Wang spoke in June 2005 at the New York Pathological Society President's Symposium on "Molecular Diagnosis and Monitoring of Non-Hodgkin's Lymphoma." She was also invited to present her work on "Comparison and Selection of the Control Gene For Molecular Monitoring of BCR-ABL" at Molecular Monitoring Of Patients With Chronic Myeloid Leukemia:

A Consensus Workshop held at the National Heart, Lung and Blood Institute, NIH. The workshop gathered together 30 experts from Europe, Australia, Canada and the United States to draw international guidelines for molecular monitoring of BCR-ABL by real time PCR. A manuscript regarding this work has been accepted for publication by the Journal of Molecular Diagnostics.

Dr. Pengbo Zhou received a Scholar Award from the Leukemia and Lymphoma Society as well as a new R01 grant from the NIH to study the role of CUL-4A ubiquitin ligase in leukemiagenesis. He also served on the Molecular Oncogenesis Study Section at NIH and the Cell Cycle and Growth Control Study Section at the American Cancer Society. His invited seminar/ presentations this year included the 2005 Cold Spring Harbor meeting on the Ubiquitin Family, the 8th International Conference on Emerging Technologies in Drug and Gene-based Therapeutics, the University of Pennsylvania, the Gladstone Institute of the University of California in San Francisco, Roche Pharmaceuticals (Palo Alto, CA), and Protein Design Labs (PDL).

The Department bids farewell to our dear friend and colleague Dr. M. Desmond Burke,who has officially retired from the Weill Medical College on November 10th, 2005. A reception was held in his honor on that day. He will be truly missed!

Dr. Daniel Knowles (right) presented Dr. Burke with a sterling Tiffany platter with a special inscription and the engraved signatures of individuals with whom he closely worked. Mr. William T. Greene, Vice President of Operations, (right) presented Dr. Burke with a pair of 18 carat gold cufflinks of the original Hospital seal.
 
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